In immunology, an idiotope is the unique set of antigenic determinants (epitopes) of the variable portion of an antibody.
Idiotopes contrast with allotopes, which are non-varying structures on the Fc receptor.
[2] This type of regulation was proposed by Danish immunologist Niels Jerne in 1974.
Because of the resemblance of anti-idiotypic antibodies to the original antigen, vaccine studies have been performed.
An anti-idiotypic monoclonal antibody was generated to possess an "internal image of cocaine".