Written by Olly Alexander and its producer Steve Mac, it was released on 10 May 2018 by Polydor Records, as the second single from the band's second studio album, Palo Santo (2018).

The music video was directed by Fred Rowson with choreography by Aaron Sillis.

The song was performed live on both the Palo Santo Tour and the Night Call Tour.

On 5 August 2022, "If You're Over Me" was certified double platinum by the British Phonographic Industry (BPI).

The song has spent a total of 23 weeks on the UK Singles Chart.