He received his early education at home, but in 1642 went to Seville, and entered the studio of Francisco Herrera the Elder.
By 1646, he was residing at Aracena, near to the mountains, and there it was that he married Doña Francisca de Chaves, but his first wife lived a very short time, and in 1649 he returned to Seville, where he married his second wife Doña Maria Escobar.
As a result of a dispute with reference to a series of pictures on the life of David, they stopped collaborating.
Murillo painted the whole of the picture representing an episode in the life of David, and Iriarte contented himself with his exquisite landscapes, as a rule wild and rugged scenes, somewhat allied to those of Salvator Rosa, in which at that time he was the greatest exponent.
The painter has been called the Spanish Claude Lorraine, and Murillo declared that his best landscapes were painted "by Divine inspiration".