Isaac Burr Butler (August 22, 1873 – March 17, 1948) was a Major League Baseball pitcher.

Butler played for the Baltimore Orioles in 1902.

In 16 career games, he had a 1–10 record, with a 5.34 ERA.

He threw right-handed.

This biographical article relating to an American baseball pitcher born in the 1870s is a stub.