Isaac Bernard Hampton (born August 22, 1951, in Camden, South Carolina) is a former Major League Baseball catcher.

Hampton made his major league debut as a pinch hitter on September 12, 1974, at Shea Stadium.

Batting for first baseman John Milner in the bottom of the 9th against Al Hrabosky of the St. Louis Cardinals, he flew out to center field.

Hampton's best year in the big leagues was 1977, when he stayed with the Angels for the entire season.

Career totals include 113 games played, a .207 batting average (28-for-135), 4 HR, 18 RBI, 15 runs scored, and a .341 slugging percentage.