In 2022, he was nominated for a Primetime Emmy Award for Outstanding Actor in a Short Form Series for his work on Cake.

[2][6][7] In 2018, Ufomadu acted in Clare Barron's off-Broadway play Dance Nation; he was part of the original cast that received a Drama Desk Award for Outstanding Ensemble.

[8] Ben Brantley of The New York Times commended Ufomadu's "appealing, low-key presence" in the female-led play.

[10] Paste magazine wrote that the title character was "skillfully played straight-faced" by Ufomadu, who co-wrote the film with director Graham Mason.

[12] Ufomadu and Mason contributed the recurring segment "Words with Ike" to the fifth season of FXX's short-form comedy anthology Cake in 2021.