[2] Approximately two liters of fluid enters the colon daily through the ileocecal valve.

A thickening of the muscularis mucosa,[citation needed] which is the smooth muscle tissue found beneath the mucosal layer of the digestive tract.

[4] Intubation of the ileocecal valve is typically performed in colonoscopy to evaluate the distal, or lowest, part of the ileum.

Small bowel endoscopy can also be performed by double-balloon enteroscopy through intubation of the ileocecal valve.

[6][7] Other benign lesions may also occur on the ileocecal valve, which are often hard to diagnose and treat surgically.