In the anatomy of the human digestive tract, there are two colic flexures, or curvatures in the transverse colon.

The hepatic flexure lies in the right upper quadrant of the human abdomen.

It receives blood supply from the superior mesenteric artery.

Splenic flexure syndrome is often found in those with irritable bowel syndrome (IBS), and is considered by some practitioners to be a type of IBS since it can also result from stress.

[3] The splenic flexure is a watershed region as it receives dual blood supply from the terminal branches of the superior mesenteric artery and the inferior mesenteric artery, thus making it prone to ischemic damage in cases of low blood pressure because it does not have its own primary source of blood.