IL 48 serves Harvel, Morrisonville, Palmer, and Clarksdale.

Continuing toward Decatur, IL 48 serves Willeys, Stonington, Blue Mound, and Boody.

The route has an interchange with US 51 before entering through the city limit of Decatur.

Between two interchanges with I-72 at Decatur and Cisco, the route serves Oreana and Argenta.

[9][10] Media related to Illinois Route 48 at Wikimedia Commons