During the reign of Imam Quli Khan, the Bukhara khanate achieved the most significant power for the entire period of its existence.
Despite a successful foreign policy, Imam Quli Khan was unable to completely overcome the internal contradictions in the state associated with the separatism of certain Uzbek tribes.
The ambassadors were greeted friendly and Jahangir sent gifts and a poem to Imam Quli Khan, which he composed himself.
In the last years of his life, Imam Quli Khan began to see poorly and in 1642 he renounced the throne in favor of his brother Nadir Muhammad (1642–1645) and went on the Hajj.
Imam Quli Khan visited the Safavid Shah, where the local artist Mo'en Mosavver painted his portrait.