It is one of the four cathedrals dedicated to the Immaculate Conception of St. Mary in Honduran territory, the others being Choluteca, Comayagua and Danlí.

According to one historian, it was Fray Antonio Bertrand in 1734 who first called for a church to be built in Juticalpa, asking for funds from the Captaincy General of Guatemala.

The high altar was built by Coronado Chávez, and it was covered with ten pounds of gold paint.

[2] The temple follows the Roman or Latin rite and is the mother church of the diocese of Juticalpa (Dioecesis Iuticalpensis).

It was created as a territorial prelature in 1949, and elevated to its current status in 1987 through the bull "Universae Dei" of Pope John Paul II.