Noble County's pioneer settlers arrived soon after the Treaty of Greenville, 1795;[2]: 117  although the area is near the earliest settlement at Marietta, the northward advance of civilization was delayed by events such as the Big Bottom massacre, 1790, on the Muskingum River not far to the west.

Construction began on a small church building under the ministry of the priest from Miltonsburg, and Archbishop Purcell of Cincinnati dedicated it in 1853.

[3] Moreover, the interior possesses complexity uncommon in rural Appalachian Ohio, due to components such as a vaulted ceiling, polychromy, and a grand high altar.

The church's dedication to the Virgin prompts its primary paint color to be a light blue, although rose and gold are extensively used as a reference to Christ the King.

It is one of nine Noble County locations on the National Register; among the others is St. Henry's Church in Harriettsville,[1] which Immaculate Conception supported in the two parishes' earliest years.