By far the majority of the high school's more than 10,000 graduates continued their education at colleges and universities nationwide.

[2] In the late 1960s, in response to directives from Vatican II as well as participation in therapy experiments run by researchers from the Esalen Institute, the Sisters followed the guidance of Pope Paul VI and conducted an extensive review of their structure and proposed changes in how they prayed, worked, lived together and governed themselves.

However, the Archbishop of Los Angeles, Cardinal James Francis McIntyre, was opposed to all of the sisters' proposed changes, leading to a public dispute where he ordered the removal of all Immaculate Heart Sisters teaching in Los Angeles diocesan schools, and finally presented the Community with an ultimatum: either conform to the standards of traditional religious life or seek dispensation from vows.

[4] Corita Kent was a member of the community and obtained her degree from IHC; she taught art at the college between 1938 and 1968.

[11] The female and male graduates of the college went on to become distinction as artists, musicians, educators, journalists, doctors, lawyers, judges, and stars of stage and screen.