However, Transportin-1 can directly bind to the cargo proteins and may not need importin alpha subunit to do it.

[9] The function of Transportin-1 in this case is thought to be similar to carrying proteins into the nucleus through a nuclear pore.

[10] Alternate splicing of this gene results in two transcript variants encoding different proteins.

In conjunction with the RanGTP hydrolysis cascade TRN1 acts to import a selection of proteins into the nucleus of cells.

[12] TRN1 has been implicated in the pathogenesis of two neurodegenerative diseases namely amyotrophic lateral sclerosis and frontotemporal dementia.