The terracotta is made from local clay, has a red-colored finish, and production includes everything from small tiles to large garden vases and statues.

The façade is preceded by a portico by Gherardo Silvani (1634), built by the Florentine people as vow for the liberation from the plague, and by a bell tower from the 13th century.

The presbytery is flanked by two niches by Michelozzo decorated by Luca della Robbia, housing the relics of the Holy Cross and the Madonna's image to which the sanctuary is devoted and, which, according to tradition, was painted by St. Luke himself.

The museum connected to the basilica is home to one of the oldest-known pieces of European patchwork, the so-called Impruneta Cushion, dating from the late 14th or early 15th centuries.

The cushion belonged to Bishop Antonio degli Agli, priest in charge of Santa Maria dell'Impruneta from 1439 to his death in 1477, and was found in his tomb after the church was damaged by an Allied bomb in 1944.