The municipality borders with Castel San Niccolò, Castelfranco Piandiscò, Figline e Incisa Valdarno, Montemignaio, Pelago, and Rignano sull'Arno.

The territory has been inhabited since ancient times and many place names indicate the presence of Etruscan, Roman and Longobards.

Initially called "Castelvecchio di Cascia", Reggello born as a marketplace near the Resco torrent where three streets meet: two trails from Casentino Valley and the Cassia Vetus (now called Setteponti road).

The 1966 flood of the Arno triggered a landslide that destroyed a neighborhood in Reggello, killing seven people.

The local football team is called S.S. Resco Reggello, now playing in Promozione division.