Her parents were Rodrigo González Girón, Lord of Frechilla, and his second wife, Teresa López de Haro.

Inés married her mother's second cousin, Infante Philip, in 1263 or 1264, after the death of his first spouse, Christina of Norway, becoming Lady of Valdeporchena, Piedrahita and Valdecorneja.

Infanta Inés died in Seville in 1265 and her husband remarried, his third wife being Leonor Rodríguez de Castro.

[citation needed] She is buried in Villalcázar de Sirga, in the Church of Santa María la Blanca.

On the lid of the tomb appears a recumbent statue representing the deceased.