In vivo supersaturation is the behavior of orally administered compounds that undergo supersaturation as they pass through the gastrointestinal (GI) tract.
Typically these compounds have a weakly basic nature (pKa in the range of 5 to 8)[1] and a relatively low solubility in aqueous solutions.
In vivo supersaturation is a recent phenomenon that was first observed by Yamashita et al. in 2003.
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