Indatraline hydrochloride (Lu 19-005) is an antidepressive agent and non-selective monoamine transporter inhibitor that blocks the reuptake of dopamine, norepinephrine, and serotonin with similar efficacy to cocaine.

[2] Lu 19-005 has been shown to block the action of methamphetamine and MDMA in laboratory experiments.

[3] Indatraline is N-alkylated at the amino group, making it possible to slow the onset of action, so that it is not until N-demethylation occurs that the molecules become active.

Effects of N-dimethylindatraline start about 20–30 minutes after administration; it takes a longer time for this chemical to absorb into the body than cocaine.

Another method involves the contraction of a dihydronaphthalene (6–6 fused system) to form the 6–5 indane skeleton.