Independence is a census-designated place and unincorporated community in Tate County, Mississippi, United States.

The settlement is approximately 7 miles (11 km) south of Cockrum and 11 miles (18 km) east of Coldwater along Mississippi Highway 305.

It was first named as a CDP in the 2020 Census which listed a population of 200.

[3] The settlement was first known as "Flewellenes Crossroads" and "Buck Snorts".

[6] By 1907, Independence had a post office, several stores/businesses, two churches, and a public school.