The team ended the tournament as runner-up with 20 points, being beaten by Legión Militar Deportiva de los Taxis Rojos, a representative of a transportation company.

On August 15, Santa Fe played its first game in the professional championship against Deportes Caldas, a match that ended 3–3.

Santa Fe finished the league as the first champion of the Colombian first division, winning 12 of 18 games, drew 3 and also lost 3.

Seeking for a new title, Santa Fe took advantage of the events of El Dorado signing Argentines Héctor Rial and René Pontoni (the former became a star of Real Madrid years later), as well the Englishmen Neil Franklin and George Mountford from Stoke City, and Charlie Mitten from Manchester United.

Santa Fe's first success in the 2000s came late, when the team won the Copa Colombia, beating Deportivo Pasto in the finals.

They began the tournament in the Second Stage, facing Cerro Porteño, Deportes Tolima and Real Garcilaso, where they finished first with 14 points and unbeaten.

That year, Santa Fe was runner-up in the Copa Colombia, losing the finals against Deportes Tolima with an aggregate score of 3–2.

In the 2014 Copa Libertadores, Santa Fe played against Monarcas Morelia in the First Stage, drawing 2–2 on aggregate score and advancing to the next round due to away goals rule.

In the Second Stage, the team was last of its group, in which they faced Atlético Mineiro, Club Nacional and Zamora, winning only one match of six.

The 2015 season had a great start for the team, as they qualified for the 2015 Copa Sudamericana after winning 2015 Superliga Colombiana in which they faced 2014 Torneo Apertura winners Atlético Nacional.

In the quarterfinals they won 2–1 on aggregate to Argentine Independiente and in the semifinals they also advanced on away goals after drawing 1–1 with Paraguayan Sportivo Luqueño.

There Santa Fe won 3–1, thus getting the first international title of the club and qualifying for the 2016 Copa Libertadores, 2016 Recopa Sudamericana and 2016 Suruga Bank Championship.

Santa Fe's Wilson Morelo tied with three footballers as top goalscorers of the tournament with five goals.

The first badge of Santa Fe was designed by Ernesto Gamboa and Gonzalo Rueda with a clear British influence.

Highlighting the Bogotá flag colors, red and yellow, combined to form the Holy Cross, a symbol of faith and respect, referring to the name of the club.

The most commonly accepted version is that Luis Robledo, one of the founders of the Independiente Santa Fe who was educated in England, was a fan of Arsenal, thus gives the team the red and white, which from 1941 became the symbol of the club.

The stadium Nemesio Camacho, also known as El Campín, located in Bogotá, is the venue where Independiente Santa Fe plays their home games.

El Campín was inaugurated on August 10, 1938, at 57th Street with 30, having started its construction in 1935 on the initiative of the mayor of Bogotá, Jorge Eliecer Gaitán.

In the late 1990s, the most notorious Barra brava of Santa Fe, La Guardia Albi-Roja Sur (White-Red South Guard) was created.

During this match Millonarios fans locate themselves in the northern part of the stadium much like Santa Fe's in the south.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

The following players were chosen to represent their country at the FIFA World Cup while contracted to Independiente Santa Fe.