The Indian Ocean Tuna Commission (IOTC; French: CTOI) is an intergovernmental organization that co-ordinates the regulation and management of tuna in the Indian Ocean.

A multilateral treaty, the Agreement for the Establishment of the Indian Ocean Tuna Commission was approved by the Council of the Food and Agriculture Organization of the United Nations in November 1993.

The agreement entered into force on 27 March 1996 after it had been accepted by a tenth party.

The Agreement is open to any state that has coasts within the Indian Ocean region (or adjacent seas) as well as any state that fishes for tuna in the Indian Ocean region.

The IOTC is the successor to the Indo-Pacific Tuna Development and Management Programme, which was established in 1982.