[7][8] On October 31, 1963, during a Holiday on Ice show, a liquefied petroleum gas leak at a concession stand caused an explosion which killed 81 people[9] and injured around 400 others.

[17] The Pacers returned for a night when they played their first pre-season game of the 2008–09 season at the Pepsi Coliseum on October 8, 2008, hosting the then-New Orleans Hornets.

Former ABA Pacers George McGinnis, Darnell Hillman, Bob Netolicky, Don Buse, Jerry Harkness, Steve Green, Tom Thacker, Bill Newton, and Wayne Pack, attended the game and were recognized during a halftime ceremony.

The Indianapolis Ice of the International Hockey League played in the Coliseum from 1988 to 1994, and again from 1997 to 1999 when the Conseco Fieldhouse was under construction, winning the 1990 Turner Cup championship.

[citation needed] On January 25, 2019, the Horizon League announced its Men's and Women's Basketball Championships would take place at the Coliseum, starting March 9–10, 2020.

[23] The Coliseum also hosts Budweiser Fight Night Boxing; the Indianapolis Boat, Sport & Travel Show; the Hoosier Horse Fair; high school and college commencement ceremonies; and many concerts featuring national acts.

[25] With the NCAA electing to hold the entirety of the 2021 Division I men's basketball tournament within the state of Indiana to prevent the spread of COVID-19, the Coliseum served as one of the sites hosting first and second-round games.

[26] On April 13, 2021, the Indiana Fever announced that they would play the last 12 home games of the 2021 WNBA season at the Coliseum due to the renovations at Gainbridge Fieldhouse.