Some of the players who have helped define the history of the Fever include Tamika Catchings, Katie Douglas, Briann January, Natalie Williams, Yolanda Griffith, Shavonte Zellous, Tully Bevilaqua, Tammy Sutton-Brown, Natasha Howard, Candice Dupree, Cappie Pondexter, Erica Wheeler, Kelsey Mitchell,Lexie Hull, Aliyah Boston, Caitlin Clark, and DeWanna Bonner.

The Fever went into the year with high expectations of a playoff berth, but Catchings tore her ACL during a college game and missed the entire WNBA season.

Her team competed well all year and posted a respectable 16–16 record, tying for the final playoff spot with the Orlando Miracle.

The team added Olympian Natalie Williams and Charlotte Sting star Kelly Miller before the 2003 season.

Kelly Krauskopf replaced Fortner as GM and immediately hired Brian Winters to be the head coach.

In the first round, the Fever swept the New York Liberty two games to none, earning their first playoff series victory in franchise history.

In the 2005–2006 offseason, the Fever acquired All-Star Anna DeForge from the Phoenix Mercury in exchange for Kelly Miller.

Later that offseason the Fever made another All-Star addition by signing free agent Tamika Whitmore from the Los Angeles Sparks.

In the 2006 WNBA draft they selected athletic swing-forward La'Tangela Atkinson from the North Carolina Tar Heels along with Kasha Terry from the Georgia Tech Yellow Jackets.

Game 2 in Detroit was a high-scoring affair with Tamika Whitmore scoring a WNBA Playoff record 41 points.

In the Dispersal Draft, the Fever added veteran forward Sheri Sam from the Charlotte Sting.

Kelly Krauskopf and the front office then set their eyes on key Free Agent Center Tammy Sutton-Brown, signing her on March 22, 2007.

The Fever also selected 6–7 center Alison Bales from Duke University in the 2007 WNBA draft to go along with Sutton-Brown.

Then on July 20, key player Tamika Catchings injured her foot causing her to miss the rest of the regular season.

On October 26, 2007, the Fever announced that they declined the option for head coach Brian Winters, ending his four-year tenure in charge.

The Fever took the owners' ultimatum to heart and reached the playoffs as the first seed overall in the Eastern Conference with a franchise best record of 22–12.

In the first round, the Fever ousted the Washington Mystics in a sweep, marking their return to the conference finals.

[13] The Fever competed for another title in 2015, reaching the finals for the third time in franchise history, but fell short losing to the Minnesota Lynx in five games.

[14] However, the Fever were upset in the first round elimination game against the Phoenix Mercury after the league's new playoff format was in effect.

[15] In February 2017, the Fever traded for five-time all-star Candice Dupree along with the Mercury's 2017 first-round pick in a three-team deal that sent Camille Little and Jillian Alleyne to the Mercury and the Connecticut Sun receiving the 8th overall pick in the 2017 WNBA draft along with Lynetta Kizer from the Fever.

[16] Despite acquiring a veteran all-star forward and a new head coach, the Fever would have one of the most disappointing seasons in franchise history.

On March 4, 2019, Pacers Sports & Entertainment announced Allison Barber, a graduate of Tennessee Temple University and Indiana University, as the new president and chief operating officer of the Fever, while Catchings was named vice president of Fever Basketball Operations.

[23] On February 14, 2022, Tamika Catchings stepped down as the vice president of basketball operations and general manager of the Indiana Fever.

Clark averaged 19.2 points, 5.7 rebounds, and a league-leading 8.4 assists per game, becoming the first true rookie to do so in league history.

[31] The sixth-seeded Fever fell to the Connecticut Sun, the first opponent in the Clark era, in a two-game playoff sweep.

Games air on WTHR, WTHR-DT3 or WALV-CD in Indianapolis, WCIX or WCIA in Champaign-Springfield, WXIX-DT3 in Cincinnati, WQAD-TV or WQAD-DT3 in Davenport, WKEF-DT3 in Dayton, WOI-TV or KCWI-TV in Des Moines, WFIE-DT2 in Evansville, WPTA-DT3 in Fort Wayne, WPBY-LD or WPBY-DT2 in Lafayette, WKYT-DT2 in Lexington, WHAS-TV or WHAS-DT2 in Louisville, and WCWW-LD, WMYS-LD or WNDU-DT2 in South Bend.