Only the segment of SR 101 that is concurrent with the U.S. Route 33 (US 33) is listed as a part of the National Highway System (NHS).

[2] The NHS is a network of highways that are identified as being most important for the economy, mobility and defense of the nation.

This measurement is a calculation of the traffic level along a segment of roadway for any average day of the year.

The highway curves around Brookville Lake and continues due north towards Liberty.

The road crosses into Union County and turns northeast again, ending at an intersection with US 27 and SR 44 in Liberty.

[8][6] The fourth and final portion is 45.03 miles (72.47 km) long and has its southern terminus at SR 124 in southeastern Adams County and heads north passing through farmland.

The concurrency ends when SR 101 turns back north and US 224 continues towards the west.