The segment of US 24 between Logansport and Toledo, Ohio, is part of the Hoosier Heartland Industrial Corridor project of the Intermodal Surface Transportation Efficiency Act.

US 24 runs concurrently with I-469 until the east side of New Haven, passing through interchanges with Maplecrest Read and SR 37 along its path.

US 24 leaves I-469 at exit 21 in New Haven, a conventional partial cloverleaf interchange, but, from there, heads northeast toward Ohio as a four-lane mostly Interstate standard rural freeway.

After leaving I-469, the US 24 freeway has a substandard (short, low-speed Y-ramps of a right-in/right-out design) interchange with Bruick Road and Old US 24 in rural Allen County.

US 24 and the state roads crossed the St. Marys River in Swinney Park then became split through downtown Fort Wayne on a one-way pair of streets, with Jefferson Boulevard and then Maumee Avenue carrying eastbound traffic and Washington Boulevard handling westbound travel.

East of downtown, SR 37 left the one-way pair of Maumee and Washington at Anthony Boulevard, departing to the north.

Just east of Fort Wayne, US 24 had an interchange with the Bueter Road alignment of the original 1953 US 30 "Bypass" (later renamed Coliseum Boulevard).

Just beyond that split, US 24 turned north onto Broadway Street, with SR 14 continuing due east along Dawkins Road to Ohio.

On Broadway, US 24 crossed the Nickel Plate railroad mainline at-grade and then curved slightly north-northwest through downtown New Haven before turning east onto Rose Avenue which led out of town (and past the point which later would become the I-469 interchange) as the old alignment which was later replaced by the modern freeway.

Though this deviation was along a two-lane road, it saved them several miles of unnecessary out-of-the-way travel along the officially shielded route.

Many through travelers, however, still use CR 900 South/Lafayette Center Road (both now widened and improved) to I-469 east and north route as it remains far shorter and more direct than the officially designated US 24 northern bypass of the Summit City and its eastern suburb.

Fort to Port[definition needed] was first brought up in a meeting by Indiana State Representative Mitch Harper, in 1989.

The Indiana Department of Transportation (INDOT) claimed that the current traffic on US 24 does not justify interchanges, even though the 2005 final environmental impact study (EIS) states that it does.

[6] The intersection with Bruick Road was to have initially been an at-grade crossing, but INDOT announced in August 2009 that a grade-separated interchange was to be built here as well.

Indiana financed construction through the Major Moves program and will be reimbursed when federal highway funds become available.

By December 2008, crews had completed construction on two miles (3.2 km) of the freeway from the Ohio state line to just east of the SR 101 interchange.

[9] In the original plans, INDOT intended to upgrade the I-469/US 24 interchange to allow free-flowing movements between the two highways as documented in the Fort-to-Port final EIS published in 2005.

[11] After a change in land use, phase 2 went through another redesign in March 2022 and a decision was made to completely replace the flyovers with a conventional loop ramp.