The road then passes through Lost Bridge State Recreation Area and crosses over the Salamonie Lake.

The road heads north towards Andrews, passing through rural farm land on the way.

Shortly after the curves the highway enters the town of Andrews concurrent with Main Street and passing through residential areas.

Main Street crosses a Norfolk Southern rail track in the center of town.

[3][4][5] SR 105 heads southwest concurrent with US 24 as a four-lane divided highway, running roughly parallel to the Wabash River.

On the way to South Whitley the road crosses SR 16 and passes through the community of Bippus.