At this point and as of September 2013 the route is discontinuous due to the transfer of several urban road segments to the city of Lafayette.

[3] Formerly the route followed Teal Road and Sagamore Parkway through the south and east sides of Lafayette.

[4] Source:[5] After I-65, SR 25 heads northeast out of Lafayette and, immediately after a roundabout, curves to the right and becomes a 4-lane limited access highway.

SR 25 then heads northeast towards Logansport, going past the communities of Rockfield, Burrows, and Clymers.

SR 25 then heads into downtown Logansport after exiting off the Hoosier Heartland Highway onto Burlington Ave.[6] State Route 25 from Lafayette to Logansport is part of the National Highway System, a network of routes deemed most important for the nation's economy, mobility and defense.

[7] In Logansport SR 25 has one way pairs with northbound on Market Street and southbound on Broadway.

SR 25 leaves Logansport on north side of town, heading north-northeast toward Rochester.