The eastern portion runs along the border between Fulton County and Marshall County; it is approximately 16.4 miles (26.4 km) long and connects SR 17 at the west end with SR 25 at the east end.

The SR 110 designation ends at US 231 but the roadway continues east as a county road.

The lowest traffic count during 2015 was at the eastern end of the western segment of SR 110, where 3,714 vehicles travel the highway on average each day.

[1][2][5] The highest traffic count for the eastern segment of SR 110 in 2016 was just west of US 31, where 1,414 vehicles travel the highway on average each day.

The lowest traffic count during 2016 was at the western end of the eastern segment of SR 110, where 984 vehicles travel the highway on average each day.