State Road 38 (SR 38) in the U.S. state of Indiana serves as a connection between Lafayette in the west and Richmond in the east.

SR 38 begins in Lafayette at the intersections of Sagamore Parkway and Main Street, just north of US 52.

It proceeds east-southeast through Frankfort and Sheridan, then through the north Indianapolis suburb of Noblesville.

It continues through Pendleton where it crosses I-69, then on through New Castle and Hagerstown.

SR 38 terminates in Richmond, where it meets US 35.