Once SR 67 reaches Indianapolis, as Kentucky Avenue, it overlaps Interstate 465 around the south and east sides of the city until Exit 42, where SR 67 and U.S. Highway 36 depart the city to the northeast as Pendleton Pike.

U.S. Highway 36 splits off from State Road 67 in Pendleton and proceeds east.

Northeast of Muncie, SR 67 wraps up its diagonal run in the same manner as it began: as a rural, two-lane highway.

SR 67 was so numbered and aligned because it was planned as a potential northeastern extension of U.S. Route 67.

The routes then overlapped U.S. 421 when they turned left onto Dr. Martin Luther King Jr. Street.