Several athletics venues are located on the campus, including the IU Michael A. Carroll Track & Soccer Stadium and Indiana University Natatorium, the largest indoor pool in the United States with a seating capacity of 4,700.

[14] IUPUI CyberLab, a lab in the School of Engineering and Technology that provides research and intellectual support for the design, development, and implementation of innovative educational technology,[15] was established in 1996 by Ali Jafari and funded by William Plater, the Executive Vice-Chancellor of IUPUI at the time.

Ali Jafari, David Mills, Brian Ho, and Amy Warner[16] was the first team at the CyberLab to start working on the development of the very first online (based on the Internet) on an Indiana University campus.

[19] In 2012, the Indiana Commission for Higher Education approved IU's proposal to create what is believed to be the world's first school dedicated to the study and teaching of philanthropy.

[24][25] The School of Science is now operated by IU along with its other programs, including business, law, nursing, and social work under Indiana University Indianapolis.

[26] IU added a new computer science programs to its School of Informatics, Computing and Engineering, and Purdue intends to open a branch of its applied research institute on or near the IUPUI campus, and plans to house several other programs in various locations throughout Indianapolis.

[28][29] The IUPUI Faculty Council said that IU President Pamela Whitten and Board of Trustees "undermined" shared governance.

While integrated into the Indiana University system budget, IUPUI was semi-autonomous in that it retains some independent control of its own academic curricula.

The entire campus is located in the 46202 zip code.The campus offers several new buildings including: The IUPUI campus is home to several nationally renowned hospitals and research entities including Riley Hospital for Children at Indiana University Health, Eskenazi Health, Richard L. Roudebush VA Medical Center, Regenstrief Institute, and the Indiana Clinical and Translational Sciences Institute.

Ball Hall, University Tower, Riverwalk Apartments, and North Hall offer Residential Based Learning Communities on designated floors, areas, or buildings where students request to live near others who are interested in a particular social cause or academic area.

The Spot is a one-stop-shop portal[56] that contains a comprehensive list of student organizations, events, FAQs, and grant information.

[63] Campus Recreation[64] provides activities that facilitate healthy lifestyles for a diverse population of students, faculty, and staff at IUPUI.

Membership provides access to swimming at the world-class IU Natatorium, fitness classes, three weight and fitness rooms, recreational open gym, access to the new IUPUI Outdoor Recreational Complex (outdoor basketball courts) and participation in the intramural program, which includes basketball, broomball, dodgeball, flag football, golf, inner tube water polo, kickball, racquetball, soccer, softball, ultimate Frisbee and volleyball.

Additionally, the stadium serves as the home field for the Indy Eleven soccer team of the USL Championship.

The growing campus serves more than 1,700 undergraduate and graduate students who live primarily in Bartholomew, Brown, Decatur, Jennings Jackson, Johnson, Ripley, and Shelby counties and offers a broad range of undergraduate degree programs in business, communication studies, elementary education, English, general studies, mechanical engineering, nursing, psychology, and sociology, as well as two graduate degree programs – Master of Business Administration and Master of Arts in Mental Health Counseling.

By July 1, 2024, IUPUC transitioned completely to Indiana University Columbus (IUC) and is now administered through IU Indianapolis.