Incumbent governor Mitch Daniels was term-limited and unable to seek a third term.

The Republican candidate, Congressman Mike Pence; the Democratic candidate, former Speaker of the Indiana House of Representatives John R. Gregg; and the Libertarian candidate, youth mentor, small business owner and reality TV personality, Rupert Boneham, were all unopposed in their respective primaries or conventions and contested the general election.

At 1:06 am, Gregg called Pence to concede, realizing there were not enough votes left to overtake him.

The second debate was held on Wednesday, October 17, 2012, at the DeBartolo Performing Arts Center in South Bend, Indiana and was moderated by Indiana Fiscal Policy Institute president John Ketzenberger.

The third debate was held on Thursday, October 25, 2012, at the WFWA PBS 39 studio in Fort Wayne, Indiana and was moderated by DePauw University Executive Director of Media Relations Ken Owen.