Indiantown Road begins at an intersection with the Bee-Line Highway (SR 710) in the middle of the wetlands in northwest Palm Beach County, approximately 10 miles (16 km) east of Indiantown and roughly six miles from the site of the fake "ghost town" of Apix.

It proceeds east with the CR 706 designation as a two-lane road with a speed limit of 55 miles per hour (89 km/h) with wetlands on either side.

It is not until an intersection with the Florida's Turnpike ramps that the road becomes three lanes in each direction and the speed limit decreases.

This was part of a large set of transformations that particularly affected Florida south of State Road 70.

[5] Upon completion of the Interstate 95 corridor, an entrance and exit ramp was constructed connecting the two routes.