[2] It is a rural community in the interior of Florida's Treasure Coast region, first established in the early 1900s, then incorporated on December 31, 2017.

Tribes fleeing southwards from the U.S. Army after the First Seminole War found the area an attractive place to settle due to a relatively higher elevation and ample hunting and fishing spots.

[5] In 1924, Indiantown was transformed when S. Davies Warfield built an extension of the Seaboard Air Line Railroad from Coleman, Florida, to West Palm Beach, passing directly through—and stopping in—Indiantown.

[6][7] Toward that end, he planned a model city, laying out streets and building a school, housing, and a railroad station.

Warfield died a year later, putting an end to plans to make Indiantown the Seaboard's southern headquarters.

The company was involved in the construction of new water and sewage systems, housing developments, docks making use of the St. Lucie River, and a 6,000-foot (1,830 m) airstrip for bringing in small cargo and civilian air traffic.

[8] Seaboard trains continued to stop at the Indiantown depot through the 1960s, but passenger service to the station was eliminated when Amtrak took over in 1971.

The Village of Indiantown was incorporated on December 31, 2017 by special state legislation, subject to approval by residents in a referendum.

[17][18] Indiantown is the home of Payson Park, one of the top thoroughbred horse racing facilities in the United States.

Among the trainers with their champion horses who have participated in this event are William Mott, Christophe Clement, Roger Attfield, Shug McGaughey, John Kimmel, and Tom Albertrani.

The Monkees frontman, Davy Jones, also kept a stable of thoroughbred horses in Indiantown, and it was here that he died in 2012 on Leap Year Day.