Indigo Prime is the umbrella name for a series of stories written by John Smith for British comics magazine 2000 AD.

Indigo Prime is an extra-dimensional agency dedicated to the maintenance and repair of breaks and distortions across the multiverse.

All Indigo Prime agents are chosen, upon their death, based on the presence of a certain gene (the "Rembrandt Index") that occurs in one in twelve million people across the multiverse; given a new body, and then trained in a range of abilities to assist them in their job.

Each agent also specializes in a role - known job descriptions are: Sceneshifters (who manipulate the physical world), Seamsters (who deal mainly with time) and Imagineers (who can influence minds and dreams).

From episode 3 of "A Dying Art" in 2000 AD #2052, Smith was replaced by Nigel Long, under the pseudonym "Kek-W".