The team has advanced to the BSN Finals only once, winning the 2012 season championship over the Capitanes de Arecibo with a record of 22–8 after having just made the playoffs for the first time in franchise history in 2009.

In 1957 Eddie Lojo joined a team that also had the "Marvelous Blondie" (rubio maravilloso) Jaime Frontera and Pedro ‘Golo’ Laracuente, his first season in the league and the only one with Mayagüez.

Gabriel Castro Rivera, known for the ‘Los Indios de mi Pueblo’ program, was a co-owner along with William Navas and Mario Quintero.

The 1972 roster included such legendary figures as Eugenio ‘Geño’ Borrero (72-79), John Burgos, José ‘Cheo’ Mangual (72–77 and 79–83) and ponceño Tomas ‘Guabina’ Gutiérrez.

The 1974 roster included Víctor Secuola and Ralph Menar and in 1975 José (Joe) Pacheco, was the best scorer of the team equipo with 18PPG.

In 1976, Alex Vega, Cesar Fantauzzi (76–77), Elket Forbes (76,77,81) and Diego Meléndez (76, 81 y 82 with Mayagüez) arrived and took the quintet's offense along with Menar.

In 1980 the approval of the entrance of players from other Latin American countries into the BSN made possible the hiring of Dominican Frank Prats, who only played for two seasons (80 and 82).

Among them were the great Teófilo ‘Teo’ Cruz, who played for "the tribe" between 1981 and 1982, when he retired from basketball and Héctor ‘El Mago’ Blondet who wore the "taíno" uniform during the 1981 season.

This season was filled with many high expectations from the fans as the team signed various veteran starting players and moved into the Sports and Recreation Palace.

With Dr. Ariel Rojas Davis, Eudaldo Báez Cruz and Dr. Iván Martínez Deliz as club owners, 1983 saw the arrival of Vicente Ithier (83-88 and 90 in Cabo Rojo), Gerry Ocasio (83–87), Bradley Pacheco (83 y 84) and Eddie Torres (1983).

These coaches while the club was in Cabo Rojo were Johnny Flores, ‘Paquin’ Abreu, Rick Shore and Don Silveri.

During that time, Alfred "Butch" Lee Edgardo Vechio and ‘Pito’ Vargas coached the team By 2001, team owner Don Luis Falto began to invest large amounts of money without skimping on expenses and brought to Mayagüez the best players and leaders available (Edgardo Vechio, ‘Butch’ Lee, Flor Meléndez).

This good-willed experiment didn't work as it was a very talented team but lacked discipline (Andrés Guibert, Lázaro Borrel, Orlando Vega, Tyler Brown, James Carter, Elmyr García, Freddie Martínez, Ferdinand Morales, Michelo Dávila, Josué Nieves, Leroy Jackson, Joe Murray, Gary Joe Burgos, Puruco Latimer, Lee Benson, Bimbo Carmona and Ricardo Dalmau.

It's worth noting that during this time Mayagüez also signed the best prospects of the decade: José Juan Barea, Alexander Galindo, Jesus Verdejo, Felix Davila y Samuel Hernandez, who became reserve players for the team because the NCAA changed its eligibility rules with respect to Puerto Rican players who formed part of the BSN as well as the NCAA.

In 2008 Eddie Casiano, former Puerto Rico national team member, retires as player, succumbing to the many lesions.

In 2009, their first season under owner Luis Vargas and Eddie Casiano as head coach, they reached their first semi finals in franchise history.

Their first win of the season came April, 3rd 2010 against fellow rivals, the San Germán Athletics in a game played at the Rebekah Colberg Coliseum in Cabo Rojo.

The team then signed Dwayne Jones, Sean Williams, Lee Nailon and Brandon Robinson to substitute these players.

Mayagüez would be in race for the eighth and final spot of the playoffs but the team had two games confiscated and reschedule to be replayed because of an ineligible player change for Herve Laminaza[further explanation needed].

After blowing an 11-point lead going into the fourth quarter with Guaynabo on March 9, 2012 for a 95–94 loss, Mayagüez won three straight to put their record at 5–2.

Their rivals and fellow neighbors the San Germán Athletics beat Mayagüez on April 7, 2012 87–79 stopping the Indios' 8-game winning streak.