[3] Because they spread slowly, they tend to have fewer signs and symptoms when first diagnosed and may not require immediate treatment.

Symptoms can include swollen but painless lymph nodes, unexplained fever, and unintended weight loss.

[5] Indolent lymphoma is usually considered incurable without the use of allogeneic stem cell transplantation, unless the disease is localised.

[1] Some have swollen lymph nodes inside their body, such as in the chest or abdomen, which can go undetected until they become very large and cause symptoms like cough or abdominal pain.

[1] The cause of indolent lymphoma is unknown, but research has identified a number of factors that increase risk.

[6] For patients who were previously diagnosed with an AIDS-defining illness, the risk of developing indolent lymphoma is 14-fold higher.

[8] Sjögren's syndrome, systemic lupus erythematosus, and tobacco smoking for more than 40 years are linked to an increased risk of Waldenstrom macroglobulinemia.

[12] Cytopenias are relatively common, but constitutional symptoms such as fever, night sweats, and weight loss are rare in the absence of transformation to diffuse large B cell lymphoma.

[16] Diagnosis of CTCL is often delayed due to the presence of multiple clinical presentations and the lack of definitive diagnostic criteria.

Patients can be misdiagnosed with a variety of benign skin conditions, including dermatitis, eczema, parapsoriasis, psoriasis, and adverse drug reactions.

[2] In Stage II, "bulky disease" means tumor mass larger than a certain size; the threshold depends on the type of lymphoma.

[2] Stage IV: The lymphoma is in one or more organs beyond the lymphatic system, such as the liver, lungs, bone marrow, or cerebrospinal fluid.

[3] Treatment is highly individualized and depends on a range of factors, including the subtype of the disease, its stage, the patient's age, and other medical conditions.

Allogeneic stem cell transplantation can be curative because of the potential for immunologic graft-versus-lymphoma effect, but there are significant concerns regarding non-relapse mortality.

[17] Treatment options include watchful waiting, radiation aimed directly at the affected lymph nodes, chemotherapy, and immunotherapy.

Other doctors believe that potentially curative radiation therapy is underused, and that this may lead to excessive treatments and costs in the long term.

[17] Although indolent lymphoma tends to progress slowly and median overall survival is more than 10 years, prognoses differs substantially both within and between subtypes.

[5][29] Some patients live many years longer than the median survival, while others die a short time after diagnosis.