The Dutch returned to Indonesia and resumed control of the council, the institute was renamed Organisatie voor Natuurwetenschappelijk Onderzoek (OPIPA, Organisation for Scientific Research) in 1948.

And in 1966 the government changed the status of DURENAS into Lembaga Riset Nasional (LEMRENAS) (National Research Institute).

LIPI directly or indirectly authorized several scientific organizations in Indonesian, as: LIPI managed four botanical gardens in Indonesia, which were all developed during the Dutch colonial period:[9] LIPI made an electric car named Marlik (abbreviation of Marmut listrik, "electrical marmot") with the specifications: 40 km/h plain, 20 km/h steep, 300 kilometers run or 8 hours active with price Rp.40 million ($4,444)/unit for city car and smart car.

[11] Together with Japan's National Institute of Technology and Evaluation, LIPI significantly increased Indonesia's microbial collection record from 200 to 6,500 between 2003 and 2009 and more than 1,800 microbes are believed to be new discoveries.

[12] The Royal Netherlands Institute of Southeast Asian and Caribbean Studies had an office ("KITLV-Jakarta", set up in 1969) in Jakarta that collaborates with LIPI.