Infanta Catherine of Castile (1403–1439) was suo jure Duchess of Villena and, by marriage, Infanta of Aragon, Countess of Alburquerque and Countess of Ampurias.

In 1418, she was married off to her first cousin and brother-in-law, Infante Henry of Aragon.

The marriage was a part of an agreement by which Henry's older brother Alfonso married Catherine's older sister Maria and by which Henry's sister Maria married Catherine's brother, King John II of Castile.

The Infanta was forced to follow her husband into exile after he failed to take the power away from her brother's favourite, Álvaro de Luna, in 1420.

The Duchess of Villena died following a miscarriage in 1439.