Inferno is a 2016 American action mystery thriller film directed by Ron Howard and written by David Koepp, loosely based on the 2013 novel of the same name by Dan Brown.

It stars Tom Hanks, reprising his role as Robert Langdon, alongside Felicity Jones as Dr. Sienna Brooks, Omar Sy, Sidse Babett Knudsen, Ben Foster, and Irrfan Khan.

[4][2] Some time after helping the Holy See dealing with an antimatter threat,[a] Harvard University professor Robert Langdon awakens in a hospital room in Florence, Italy.

Dr. Sienna Brooks, the doctor tending to him, reveals that he is suffering from amnesia as a result of a bullet wound to the head.

They soon realize this is the first clue in a trail left by Bertrand Zobrist, a dangerously unstable villain who believed that rigorous measures were necessary to reduce the Earth's growing population, and who committed suicide three days earlier after being chased by armed government agents.

Langdon and Brooks figure out that Zobrist, who was obsessed with Dante, has created a biological superweapon he has dubbed "Inferno", with the potential of annihilating half the world's population.

Vayentha reports to her employer Harry Sims, the CEO of a private security company called "The Consortium", who is acting on behalf of Zobrist, who gives her instructions to kill Langdon as he had become a liability.

Along the way, Langdon discovers that he helped a friend of his steal and hide the Dante death mask, a crucial clue, an event that he also does not remember.

Sims reveals he was hired by Brooks to kidnap Langdon when Zobrist had been killed, and drugged with benzodiazepine to induce a memory loss; the events in the hospital were all staged.

Sims incapacitates a disciple and kills another but is fatally stabbed by Brooks who, refusing Langdon's pleas, releases the weapon by manually triggering an underwater blast.

On July 16, 2013, Columbia Pictures set Ron Howard to direct Dan Brown's fourth novel in the Robert Langdon series, Inferno, with David Koepp writing the script.

[9] On August 26, 2014, Sony had finalized the deal with Howard and Hanks, and set the film for April start of production in Italy.

[10] On February 17, 2015, studio revealed the confirmed cast for the film, including Jones as Dr. Sienna Brooks, Omar Sy as Christoph Bruder, Irrfan Khan as Harry "The Provost" Sims, and Sidse Babett Knudsen as Elizabeth Sinskey, head of the World Health Organization.

Some second unit stunts were filmed by Wade Eastwood at an apartment building close to the Ponte Vecchio, in Florence.

[2] In the United States and Canada, Inferno was initially expected to top the box office with around $25 million from 3,546 theaters in its opening weekend.

The website's critical consensus reads, "Senselessly frantic and altogether shallow, Inferno sends the Robert Langdon trilogy spiraling to a convoluted new low.

And while you're obviously meant to take Inferno with a dash of salt, it's so preposterously stupid and dumb that this rancid popcorn flick becomes increasingly nauseating the further you taste.