"[9] ITIF has called for the United States government to implement a national manufacturing strategy to combat job losses and the trade deficit which they attribute to declining international competitiveness.

[16][17] They oppose applying Title II telephone regulations to broadband, arguing that it would stifle Internet innovation, and instead support net neutrality legislation.

[21][22] Along with the Breakthrough Institute, ITIF has called for increased public funding for clean energy innovation, arguing that the United States is falling behind countries like China, Japan and South Korea.

[29][30] In the life sciences field, ITIF published Leadership in Decline: Assessing U.S. International Competitiveness in Biomedical Research in 2012, which director of the National Institutes of Health and leader of the Human Genome Project Francis S. Collins deemed the "one book" he would require President Barack Obama to read in his second term in office.

Commenting on the study, former Dean of Wisconsin School of Business Michael Knetter agreed with the productivity figures, though expressed caution given that some of ITIF's contributors are in the technology industry.

[35] In 2013, the think tank published a widely cited report which found that the U.S. National Security Agency's PRISM electronic data surveillance program could cost the U.S. economy between $21.5 and $35 billion in lost cloud computing business over three years.

[56] In 2010, ITIF received funding from the U.S. Election Assistance Commission to study means for improving voting accessibility for U.S. military service members who have sustained disabling injuries in combat.