Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia accompanied by variable neurological dysfunction, kidney failure, and fever.
It is caused by severely reduced activity of the von Willebrand factor-cleaving protease ADAMTS13.
Hereditary TTP, caused by ADAMTS13 gene mutations, is much less common.
[1] This article incorporates text by Romão de Souza et al. available under the CC BY 4.0 license.
This genetic disorder article is a stub.