[11] Later, a drug formulation called Lipostabil containing 5% PC and 2.5% deoxycholate (DC) was approved in Germany and used in the treatment of fat embolism,[12][13] dyslipidemia,[14] and alcohol-induced liver cirrhosis.
[16] In 2015, the US Food and Drug Administration approved deoxycholic acid (branded as Kybella) for use as an injection lipolysis product when used to reduce moderate to severe submental fullness (double chin).
[17][18][19] While the procedure is generally considered safe when performed by a qualified healthcare professional, potential side effects may include swelling, bruising, numbness, and rarely, nerve injury in the treated area.
[17][18][20] Three medical associations have issued health warnings cautioning against the use of injection lypolysis, including the American Society of Plastic Surgeons (ASPS), the American Society for Aesthetic Plastic Surgery (ASAPS), and the American Society of Dermatologic Surgery (ASDS).The Aesthetic Surgery Education and Research Foundation has funded on behalf of the American Society for Aesthetic Plastic Surgery a half side comparison study with interesting results[21] On April 7, 2010, the US Food and Drug Administration issued Warning Letters to six U.S. based medspas and a company in Brazil for making false or misleading statements on their Web sites about drugs they claimed will eliminate fat in a procedure called "lipodissolve", or for otherwise misbranding lipodissolve products.
The warning letters were issued to the following U.S. companies: Monarch Medspa, King of Prussia, Pa; Spa 35, Boise, Idaho; Medical Cosmetic Enhancements, Chevy Chase, Md.
Additionally some of the letters indicate that the companies have made claim that lipodissolve products can be used to treat certain medical conditions, such as male breast enlargement, benign fatty growths known as lipomas, excess fat deposits and surgical deformities.
As of July, 2005, The Medical Protection Society, the organization that provides British doctors with legal advice and coverage against litigation costs and damages, ceased offering malpractice insurance for use of Lipodissolve because of safety concerns.