At the 2012 European Championships she defeated reigning Olympic silver medallist Arianna Errigo in the semi-finals and prevailed over teammate Kamilla Gafurzianova to earn her first senior individual title.

[6] Deriglazova was left extremely frustrated by her Olympic experience and resolved to train harder under the new direction of Stefano Cerioni, former coach of the Italian foil teams.

Her ambitions for the 2013 European Championships in Zagreb were however cut short in the first round of the individual event by World No.88 Anastasiya Moskovska.

Deriglazova bounced back by taking the gold medal at the 2013 Summer Universiade after defeating teammate Larisa Korobeynikova in the final.

In the team event, Russia were defeated by France in the semi-finals, but prevailed over South Korea to earn the bronze medal.

[citation needed] In the pre-Olympic season of 2015, Deriglazova climbed the podium three times at the World Cups, winning bronze medals in Saint-More, Algeria and Tauberbischofsheim (defeats to Lee Kiefer and twice to Errigo in the semifinals).

[citation needed] At the 2019 European Championship in Germany, she lost the final to Italian Elisa Di Francisca and won a silver medal.

[citation needed] At the Olympic Games in Tokyo in July 2021, Deriglazova was the favorite in the individual championship, but won only silver, losing to American Lee Kiefer in the final.