[citation needed] When his uncle Giovanni de' Medici was elected pope in March 1513, benefits flowed even more abundantly to the Cybo.

For a brief three months in 1521 he was Cardinal Camerlengo of the Holy Roman Church but was 'allowed' to sell the office for the sum of 35,000 ducats to another of Leo's favourites, Cardinal Francesco Armellino de' Medici[8] He accumulated the rights of administration over episcopal sees, e.g. St Andrews (13 October 1513—13 November 1514),[9] Marseille, Aleria in Corsica (19 June 1518 – 19 December 1520), Ventimiglia (27 July 1519 – 8 August 1519) and numerous others, most for brief periods of time.

Once his name was suggested he managed about twenty votes, apparently from the younger cardinals, those desirous of continuing the habits of the court of Leo X.

[10] King Francis I of France appointed him Abbot of Saint-Victor of Lerins in 1522, hoping, no doubt, to strengthen the French interest in the College of Cardinals after the election of the minister of Emperor Charles V to the papal throne as Adrian VI.

A report to the Venetian Senate, written by Antonio Sorano, its ambassador at Rome, on 18 July 1531, provides an analysis of Cardinal Cibo, as his assignment required.

[citation needed] The favoured candidate was Reginald Pole, but Giovanni Maria Ciocchi del Monte, Julius III, was elected.

He was buried in the Basilica of Santa Maria sopra Minerva, in the centre of the Choir, behind the High Altar, between the monuments of his uncle Leo X and his cousin Clement VII.