Comprehensive interdisciplinary analysis is ensured by close collaboration with specialists, academic and non-academic, in political, economic, legal, historical and strategic studies and an ever-growing network of think tanks, research centers and universities in Europe and abroad.

Its headquarters are in Palazzo Clerici, a splendid example of 18th-century Milanese patrician building which boasts among its treasures the famous room with a Tiepolo fresco.

Starting from the 1950s, it organized each year a postgraduate course for young people aiming to embark on a diplomatic career or work in the sphere of international economics and politics.

The Austrians, indeed, entrusted the Ducat's internal governance to Clerici's Family, who therefore needed a mansion house in Milan and the palace subsequently became one of the most sumptuous, luxurious residences in the city.

The results of ISPI research projects are circulated in the quarterly Ispi-Relazioni Internazionali, which also publishes previews and synopses as well as in a series on international issues entitled Policy Brief.

Research activity at the Institute is organized by Centres (Asia; Cybersecurity; Europe and Global Governance; Business Scenarios; Middle East and North Africa; Radicalization and International Terrorism; Russia, Caucasus and Central Asia) and Programmes (Africa; Energy Security; Latin America; Migration; Transatlantic Relations).

ISPI's Winter and Summer School offer students, new graduates and young professionals the opportunity to gain an introduction into major international themes through a catalogue of short intensive courses on such subjects as: Development and Cooperation, Humanitarian Emergencies, European affairs, Electoral Assistance, Human Rights Democratization, Geopolitics.