Promundo's work engages women, girls, boys and men; strives to transform gender norms and power relations within key institutions; and is based on building local and international partnerships.

The institute has concentrated on developing evaluated interventions and advocacy strategies to achieve gender equality with a focus on engaging men and boys in changing inequitable and violent forms of masculinities.

In recent years, Promundo has been increasingly recognized for promoting the role of men and boys in achieving gender equality.

In 1999 Promundo, together with ECOS Comunicação em Sexualidade (São Paulo, Brazil), Instituto Papai (Recife, Brazil), and Salud y Género Archived 2011-11-26 at the Wayback Machine (Mexico), with support from the Pan American Health Organization (PAHO), the World Health Organization (WHO), International Planned Parenthood Federation/Western Hemisphere Region (IPPF/WHR), JohnSnowBrasil and Durex – SSL International developed the Program H (H for Portuguese: Homens and Spanish: Hombres, the words for Men).

It consists of educational workshops, community campaigns and innovative evaluation instruments for assessing the program's impact on young women's gender-related attitudes and perceived self-efficacy in interpersonal relationships.