[5][3] The 1946 tournament was notable for being the place where major league scout Joe Cambria signed Chico Carrasquel, then playing for Caracas.

In 1964, the champion of the Nicaraguan League became the fourth team, after Venezuela opted to instead play an interleague series against the Dominican Republic.

[11] The series struggled economically, due to the absence of Cuba as well as of the Dominican Republic, which itself was wracked in political turmoil and had been sanctioned by the Organization of American States since 1960.

[29] The Dominican Republic organized a tournament in 1965 that is sometimes referred to as the final edition of the Interamerican Series, inviting Venezuela and Puerto Rico.

[11] Major league stars like Roberto Clemente and Felipe Alou participated, but the series ended prematurely.