Venezuela debuted in international competition at the 1938 Central American and Caribbean Games in Panama City, finishing sixth.

Venezuela won its first international baseball title the following year, defeating defending champions Cuba at the 1941 Amateur World Series in Havana.

The victory of the 1941 AWS is cited as the catalyst for baseball's exploding popularity in Venezuela,[5][6] Venezuelan President Isaías Medina Angarita declared October 22, the day of the championship game, a national holiday.

Venezuela competed in the 2009 World Baseball Classic, playing its opening games in Pool C, in Toronto, Ontario.

Their placing as the third team in Pool C after defeating newcomers Spain was sufficient to secure direct qualification to the 2017 World Baseball Classic.